Regularization may be used as an alternative to dimensionality reduction when the number of variables in a model is much larger than the number of available observations. In a recent study from our group regularized regression was employed to quantify brain functional connectivity in a sample of healthy controls using a brain parcellation and resting state fMRI images. Here regularization is applied to evaluate resting state connectivity abnormalities at the voxel level in a sample of patients with schizophrenia. Specifically, ridge (...) regression is implemented with different degrees of regularization. Results are compared to those delivered by the weighted global brain connectivity method, which is based on averaged bivariate correlations and from the non-redundant connectivity method, a dimensionality reduction approach that applies supervised principal component regressions. Ridge regression is able to detect a larger set of abnormally connected regions than both GBC and NRC methods, including schizophrenia related connectivity reductions in fronto-medial, somatosensory and occipital structures. Due to its multivariate nature, the proposed method is much more sensitive to group abnormalities than the GBC, but it also outperforms the NRC, which is multivariate too. Voxel based regularized regression is a simple and sensitive alternative for quantifying brain functional connectivity. (shrink)

In the text we approach the trajectory of the Peruvian thinker Aníbal Quijano and how he came to the formulation by which he is known, the explanatory pair modernity / coloniality. We propose a problematizing reading of his intellectual itinerary, recovering a recurrent and highly suggestive metaphor in his approach, the explanatory allegory of the knot. We consider that this figure has multiple potentialities, both in the epistemic-philosophical and political-cultural dimension.

Cognitive symptoms after COVID-19 have been increasingly recognized several months after the acute infection and have been designated as “brain fog.” We report a patient with cognitive symptoms that started immediately after COVID-19, in which cerebrospinal fluid biomarkers were highly suggestive of Alzheimer’s disease. Our case highlights the need to examine patients with cognitive symptoms following COVID-19 comprehensively. A detailed assessment combining clinical, cognitive, and biomarker studies may help disentangle the underlying mechanisms associated with cognitive dysfunction in each case. The (...) investigation of neurodegenerative processes in an early stage, especially in older patients, is probably warranted. (shrink)

En el marco de la reflexión sobre las relaciones entre ética y política como dimensiones de la experiencia humana y de la vida en común, se presenta una aproximación comparativa a la noción de democracia del filósofo estadounidense John Dewey y la del neozapatismo mexicano. Se señalan algunos puntos de encuentro entre estas nociones, principalmente, la consideración de la democracia como forma de vida comunitaria, como ethos, no sólo como forma de gobierno, y la afirmación de la coexistencia entre lo (...) diverso, en distintas escalas, como condición de la democracia —el pluralismo en Dewey y el pluriversalismo en el neozapatismo—. Se indican también importantes diferencias como el énfasis en el desarrollo de las potencialidades humanas individuales presente sólo en Dewey, y la historicidad y las relaciones de poder que contempla la noción de democracia de los neozapatistas, a diferencia de la de Dewey. El texto afirma la posible fecundidad del diálogo entre distintas tradiciones de pensamiento para la comprensión de la democracia en un sentido más radical, en el que se imbriquen ética y política. (shrink)

El uso prolongado de la voz es un factor de riesgo para el desarrollo de patologías vocales en docentes. Actualmente, estos profesionales se ven obligados a usar mascarilla para dictar sus clases, lo que puede resultar en alteraciones vocales. Durante la virtualización de las clases los docentes debieron adaptar algún espacio doméstico para desempeñar sus funciones frente a un computador, disminuyendo la actividad física y fomentando un estilo de vida sedentario, lo que pudo ocasionar algún trastorno músculo-esquelético. Con este panorama, (...) el propósito del estudio es identificar efectos en la voz por la mascarilla y lesiones músculo-esqueléticas en docentes. (shrink)

Introduction: Loss of employment is an experience that is lived and interpreted differently depending on a series of individual variables, including the psychological resources available to the affected person, as well as their perception of their degree of employability. Losing one’s job can be one of the most painful and traumatic events a person has to withstand. Following a dismissal, the worker needs to overcome a period of emotional adaptation to the loss. But that period of grieving can also condition (...) the process of job search of the person, and be influenced by different variables, highlighting the age and work experience. The objective of this study is to analyze the relationship between intensity and type of affliction due to the loss of employment in older workers and their level of employability. Method: We carried out a descriptive, analytical, cross-sectional study. The sample consisted of 140 unemployed participants, from 19 to 65 years of age, users of job Orientation in the Public Employment Service of Andalusia (España). Of the total participants, 66 were unemployed and over 45 years of age. They all took the Labour Insertion Potential Assessment Test, and the Texas Inventory revised adapted to job loss Results: Significant differences are shown in the grieving process due to loss of employment between both groups, with the older unemployed living the process more intensely. In relation to the employability potential, differences are found between both groups in terms of availability, perceived difficulties and fears. Interrelationships between total grieving intensity and the importance that older jobseekers give to work are also indicated. Conclusion:Loss of employment and the psychological and health consequences of this situation are identified with those that arise in the grieving process. Older workers present a series of features that determine that their job loss grieving process is more intense and lasts longer than that of other younger workers, regardless of whether the job loss was recent or not. On the other hand, it is shown that the intensity of grieving is related to the decrease of certain variables that are part of the concept of employability. (shrink)

This article explores how historical narratives affect the evaluation of political decisions regarding justice during peace negotiations. Specifically, this study evaluates how different narratives of the Colombian armed conflict relate to the preference for either restorative or retributive justice. Results revealed that a historically accurate narrative that included structural elements correlated with the preference for restorative justice, whereas a schematic narrative that focused on individual greed favoured the preference for retributive justice. These results are explained in terms of the characteristics (...) of expert historical narratives, which include structural elements, such as economic and institutional factors. The presence of these elements in the explanation of conflicts decreases the weight of individual decisions and, in this way, prevent ingroup attributional biases. (shrink)

Durante la Ilustración escocesa se legitimó la “perspectiva del espectador imparcial” como garantía de juicios morales imparciales. Esta escuela de pensamiento se ha considerado tradicionalmente como la antesala del utilitarismo. Sin embargo, actualmente se sostiene que, aunque Hutcheson y Hume sí son protoutilitaristas, la teoría de Smith es la primera gran crítica al utilitarismo. En este ensayo atribuyo esta diferencia a la posición desde la que juzga el espectador —tercera o segunda persona— de la que se derivan estructuras metaéticas distintas (...) que condicionan, entre otras cosas, el significado de la noción de imparcialidad. (shrink)

This article discusses Aristotle’s doctrine of intellectual virtues in Nicomachean Ethics. The author describes all the intellectual virtues that Aristotle indicates, but mainly focuses on some “secondary” virtues that clarify the concept of reasonableness, with a detailed unpacking of the concepts of “consideration” and “consideration for others”. In addition to commenting on the interrelation of the moral and intellectual virtues, the article also shows why Aristotle must recognize “natural virtues” along with the virtues in the substantive sense of the word.

The most important difference between contemporary compatibilist and libertarian theories is not the difference in their positions regarding the truth of the thesis of physical determinism, but their different approaches to the causal role of agents. According to libertarians, volitional acts performed by agents constitute a specific type of causes, which are not themselves caused by other causes. In this respect, event-causal libertarianism is similar to the agent-causal libertarianism, because it insists that in performing a volitional act an agent can (...) choose one of the alternative outcomes without being caused to do so by anything else, where ‘anything else’ includes all the facts about the past and the present. Since event-causal libertarians maintain that volitional acts and the causal role of agents can be explained naturalistically, they must solve the problem of luck, i.e., they must explain how an agent is able to control her choices, given that she can choose one way or another without there being any difference in her state immediately preceding the moment of choice. This problem arises not from the indeterminism per se, but from the way it is coupled with the causal role of agents.In section one, I consider the historical development of compatibilist views on physical determinism and indeterminism. In section two, I present an overview of conditional analyses of alternative possibilities. In section three, I analyze the reasons why libertarians reject any type of conditional analysis, and show that intuitive objections against physical determinism, which portrait it as an obstacle to freedom, are untenable. In section four, I consider the consequence argument and show how it is related to the libertarian condition of sourcehood. In the final section, I analyze the problem of luck and show that it inevitably arises for any version of libertarianism. I demonstrate that indeterminism is a problem for libertarians, although they need it. And it is not a problem for compatibilists, who, while they do not need it, can incorporate it in their theories without facing the problem of luck. (shrink)

Willusionists claim that recent developments in psychology and neuroscience demonstrate that consciousness is causally inefficient [Carruthers, 2007; Eagleman, 2012; Wegner, 2002]. In section 1, I show that willusionists provide two types of evidence: first, evidence that we do not always know the causes of our actions; second, evidence that we lack introspective awareness of the causal efficiency of our intentional acts.In section 2, I analyze the first type of evidence. Recent research in the field of social psychology has shown that (...) irrelevant factors affect human behavior. For example, it has been shown that pleasant smells make a person more helpful toward strangers [Baron, 1997], whereas images of eyes that a person sees on a poster reduce the likelihood of cheating [Bateson, Nettle, & Roberts, 2006]. I argue that minor influences do not necessarily lead to something more sinister, and the contrary has not been empirically proven so far.In section 3, I analyze the second type of evidence that Daniel Wegner [2002] provides in favor of willusionism. Wegner claims that conscious will is usually understood in one of two ways: «as something that is experienced when we perform an action» [Wegner, 2002, p. 3] or «as a force of mind, a name for the causal link between our minds and our actions» [ibid.]. According to Wegner, it is a conceptual truth that for something to count as an instance of conscious will it must both be felt as voluntary, and causally efficient in bringing about a certain effect. Wegner claims that what satisfies can fail to satisfy, and vice versa. The major part of Wegner’s book is the review and analysis of diverse psychological phenomena: automatisms, hypnosis, illusions of control, influence of unconscious factors on human behavior, as well as some neuroscientific data. I briefly review the data provided by Wegner, and come to the conclusion that, although they show that there is a double dissociation between consciously willed processes and the acts that are supposedly caused by these processes, they do not justify further conclusions made by Wegner.According to Wegner, the feeling of conscious will is just an indicator of unconscious processes which, in fact, cause our behavior. I argue that the data considered by Wegner do not provide direct information about the neuronal processes that underlie conscious intentional processes. Moreover, double dissociation can only show that one process neither a necessary nor sufficient cause of another process. It cannot show that one process is not among the causes leading to another process.In section 4, I argue that the experimental data discussed in the article are important for philosophical theories of intentionality. (shrink)

This paper aims to determine whether it is necessary to propose the extreme of putrefaction as the only unmistakable sign in diagnosing the death of the human organism, as David Oderberg does in a recent paper. To that end, we compare Oderberg’s claims to those of other authors who align with him in espousing the so-called theory of hylomorphism but who defend either a neurological or a circulatory-respiratory criterion for death. We then establish which interpretation of biological phenomena is the (...) most reasonable within the metaphysical framework of hylomorphism. In this regard, we hold that technology does not obscure the difference between life and death or confect metaphysically anomalous beings, such as living human bodies who are not organisms or animals of the human species who are informed by a vegetative soul, but instead demands a closer and more careful look at the “fuzzy area” between a healthy organism and a decaying corpse. In the light of hylomorphism, we conclude that neurological and circulatory-respiratory criteria are not good instruments for diagnosing death, since they can offer only probabilistic prognoses of death. Of the two, brain death is further away from the moment of death as it merely predicts cardiac arrest that will likely result in death. Putrefaction, the criterion that Oderberg proposes, is at the opposite end of the fuzzy area. This is undoubtedly a true diagnosis of death, but it is not necessary to wait for putrefaction proper—a relatively late stage of decomposition—to be sure that death has already occurred. Rather, early cadaveric phenomena demonstrate that the matter composing a body is subject to the basic forces governing all matter in its environment and has thus succumbed to the universal current of entropy, meaning that the entropy-resisting activity has ceased to constitute an organismal unity. When this unity is lost, there is no possibility of return. (shrink)

This authoritative new book details the most recent advances in clinical neuroscience, from neurogenetics to the study of consciousness.

For almost 50 years, the Council of Europe through a series of documents has been helping to build up a set of rules, principles, and strategies related to culture, environment, ethics, and sustainable development. At the moment, one of the most important aims of the Council of Europe’s agenda deals with the elaboration of the General Principles for the Protection of the Environment and Sustainable Development, as raised in document CO-DBP (2003)2 related to the environmental subject. The intention of the (...) Council of Europe is to encourage national authorities to implement these General Principles into their national environmental policies. These principles should have an important effect, especially in those countries which are new members of the European Union. The primary target of this paper is the study of these principles and the setting of their entailed implications in order to establish a relation between values and policy making. Quite often, the conclusions adopted by the agreements generated within the framework of the European Union are controversial. Therefore, a study aiming to lay the foundations of these principles will make the exchange of ideas easier, providing a wider and more detailed scope in the European environmental policy. (shrink)

This paper proposes that the particular moral point of view embodied in Adam Smith's ethics, which ultimately follows a model based on the determination of justice, enables him to introduce impartiality as a measure for every virtue, and to posit the equal dignity of all human beings as the justification of his ethics. This moral viewpoint, which I here call the `sympathetic-impartial perspective', is naturally learned by human beings in the course of socialization through the ongoing interaction between the innate (...) impulse to sympathize and practically-informed reason. Moreover, this particular perspective creates a bridge between Smith's moral and political theories, shedding new light upon the moral foundations of his `system of natural liberty'. (shrink)

Current philosophical studies of the implications of a "minimalist" theory of truth reveal how problems otherwise unnoticed are arisen by the issue of true or false. As catalyzer of linguistic problems, this issue appears even today as a dark mirror wherein language reflects its profound enigmas and unavoidable uncertainties.

ResumenLeo Strauss, en un ambiente filosófico adverso, tuvo la osadía de interrogarse acerca de la mejor forma de vida. Sin embargo, no parece haber alcanzado acabadamente su meta. El carácter zetético de su gnoseología, el abandono de conceptos metafísicos indispensables para alcanzar la unidad de ser, su énfasis en la «negatividad» del método socrático que limita la «positividad» propia de la mayéutica: el amor a la verdad, etc. le han conducido a la aporía consistente en la imposibilidad de alcanzar una (...) síntesis entre razón y revelación, consideradas como «totalidades» incompatibles entre sí. Por ello, no llega a dar respuesta a su interrogante más profundo.Palabras claveLeo Strauss, razón-revelación, escepticismo moderado, mayéutica.AbstractIn philosophical adverse times, Leo Strauss dared question about the best way of life. However, he does not seem to have achieved his objective completely. His zetetic epistemology; the abandonment of key metaphysical concepts necessary to comprehend the unity of being; his stress on the negativity stage of the Socratic method, limiting the conclusive positive stage of the maieutic (love of wisdom) have led him to an aporia. This is the impossibility of reaching a synthesis between reason and revelation, considered as «wholes» incompatible with each other. Hence he doesn’t find a convincing answer to his deepest inquiry about the best way of life.KeywordsLeo Strauss, reason-revelation, moderate scepticism, mai. (shrink)

In this paper I propose that Adam Smith’s Theory of Moral Sentiments provides a solution to a well-known problem in contemporary ethical debate, i.e. the incompatibility between classic virtue ethics which is particularistic and informed by an ideal of virtue on the one hand, and modern principle-based ethics which attributes a prominent place to universal rules on the other. Smith acknowledges the incompatibility of these two paradigms. But, in order to preserve the advantages of both kinds of theories, he proposes (...) a third kind of moral theory: This theory can account for ancient-like virtues and judgments sensitive to the particularities of a specific context as well as for a limited set of universal rules, namely the ‘rules of justice’. The clue to this move is a change of the point of view from which moral judgments are assessed to what I call a ‘sympathetic-impartial perspective’. With this original approach Smith succeeds in articulating in a single and coherent theory the apparently irreconcilable elements of ancient and Modern accounts of morality. (shrink)

The analysis of the irregular moral sentiments that Smith describes in TMS II.iii evidences the enormous influence of David Hume’s theory of passions in the moral theory of his successor, as well as the critical differences between these Scottish philosophers’ moral proposals. Moreover, these atypical situations also allow us to grasp the different parts of Smithian moral judgment, and to exclude – despite Smith’s assertion – the influence of moral luck on these judgments.Keywords: Adam Smith, David Hume, moral judgment, passions, (...) moral luck. (shrink)

This article presents fashion as a mechanism of domination and political legitimacy, focusing on Soviet-type state socialist regimes. In particular, it documents some dynamics shaping the politics of fashion in the socio-political context of 1960s Cuba arguing that the consolidation of a radically new political order in the country was based, in part, on the production of denotative logistics that associated clothes with political values. The article concludes that denotative logistics are activated as mechanisms of impersonal rule in periods of (...) political transition or regime change, such as after the triumph of the Cuban Revolution. In those moments, they articulate processes of social engineering oriented toward producing a new society and a new man. (shrink)

Synchronic and diachronic unity of consciousness and their in­terrelation pose interdisciplinary problems that can only be addressed by the combined means of philosophical and scien­tific theories. In the first part of the article the author briefly reviews psychological and materialistic accounts of personal identity. Historically these accounts were introduced to solve the problem of diachronic identity of persons, i.e., the problem of their persistence through time. She argues that they don’t explain how synchronic unity of consciousness, subjectively experienced as the (...) unity of the phenomenal field, correlates with diachronic identity of persons. In the second part of the article the author reviews Tim Bayne’s “virtual phenomenalism”. In the third part of the article she formulates two questions that virtual phenomenalism has to answer in order to solve the problems that face both the psychological and the materialistic accounts of personal identity. The first question concerns some cognitive and neurobiological characteristics of consciousness that Bayne invokes in order to propose an original solution of the problem of the synchronic unity of consciousness. It might be asked whether the same characteristics can undermine Bayne’s solution of the problem of the diachronic unity of consciousness. The second question is a development of Bernard Williams’ arguments against psychological accounts of personal identity. The author suggests that similar arguments can be used against virtual phenomenalism. (shrink)

Initially identified as a key phosphoinositide that controls membrane trafficking at the Golgi complex, phosphatidylinositol‐4‐phosphate (PI4P) has emerged as a key molecule in the regulation of a diverse array of cellular functions. In this review we will discuss selected examples of the findings that in the last few years have significantly increased our awareness of the regulation and roles of PI4P in the Golgi complex and beyond. We will also highlight the role of PI4P in infection and cancer. We believe (...) that, with the increasing number of regulators and effectors of PI4P identified, the time is ripe for a more integrated approach of study. A first step in this direction is the delineation of PI4P‐centered molecular networks that we provide using data from low and high throughput studies in yeast and mammals. (shrink)

As a leading measure of journal quality, acceptance rates of journals can influence faculty recruitment, salary, tenure and promotion decisions; subscription decisions; and authors’ intention to submit manuscripts. Recent literature from both the Communication and Hospitality Management disciplines suggests that there are wide differences in the formulas used by editors to calculate acceptance rates. Because differing methods of acceptance rate calculation potentially impact significant decisions, a universally accepted and applied standard could be developed. A normative standard, grounded in a specific (...) core ethical principle, is generally preferable to a nonfoundational approach. Two primary approaches to the study of ethics have prevailed through time, teleological ethics with a focus on consequences as represented by Mill’s Utilitarian ideals and deontological ethics with a focus on duty as represented by Kant’s Categorical Imperative. This analysis applies these two ethical frameworks, utility and duty, to the journal editors’ dilemma of finding a common, normative method to calculate acceptance rates. (shrink)

Volume 19, Issue 10, October 2019, Page 61-63.

The COVID-19 pandemic highlights the relevance of adequate decision making at both public health and healthcare levels. A bioethical response to the demand for medical care, supplies and access to critical care is needed. Ethically sound strategies are required for the allocation of increasingly scarce resources, such as rationing critical care beds. In this regard, it is worth mentioning the so-called ‘last bed dilemma’. In this paper, we examine this dilemma, pointing out the main criteria used to solve it and (...) argue that we cannot face these ethical issues as though they are only a dilemma. A more complex ethical view regarding the care of COVID-19 patients that is focused on proportional and ordinary treatments is required. Furthermore, discussions and forward planning are essential because deliberation becomes extremely complex during an emergency and the physicians’ sense of responsibility may be increased if it is faced only as a moral dilemma. (shrink)

Antroposofische verkenning naar het begin van alle denken en zijn bij de Griekse wijsgeer.